Arnab Mukherjee
Associate Professor, IISER Pune
E-mail: arnab.mukherjee[at]iiserpune.ac.in
Brief Bio-sketch:
Received Ph.D. in theoretical chemistry from IISc Bangalore on 2005. Then I went for postdoctoral research in ENS, Paris and University of Colorado, Boulder with J. T. Hynes. I joined IISER Pune as assistant professor on 2009.
DNA STRUCTURE FROM ITS SEQUENCE USING BASE-STEP FREE ENERGY AND MACHINE LEARNING
In this talk, I will discuss about the prediction of DNA structures from its sequence using two different approaches: a statistical mechanical approach and a machine learning approach. While the free energy cost of B→A DNA transition at the dinucleotide level was used to predict the 'B' or 'A' DNA in the statistical mechanical model, a machine learning approach based on classification algorithm was used to predict the structure from the sequence. Finally, we will show a correspondence between both the approaches.